Immobilization of Amylase on Magnetic Nanoparticles Essay

Unique ÃŽ ±-amylase was immobilized covalently on iron oxide attractive nanoparticles. The blend of attractive nanoparticles was finished by the coprecipitation ordinary technique. The substance structure and molecule size of the blended particles was affirmed through X-beam diffraction. Tyrosine, Lucien and chitosan and glutaraldehyde were explored to make a covalent official between the iron oxide attractive center and the immobilized protein. Immobilization utilizing chitosan and glutaraldehyde show the best outcome. At last the immobilization productivity was tried by assurance of protein focus in an answer when blending in with the attractive nanoparticles. Presentation Over the most recent two decades, new terms with the prefix 'nano’ have hurried into the logical jargon; nanoparticle, nanostructure, nanotechnology, nanomaterial, nanocluster, nanochemistry, nanocolloids, nanoreactor, etc. Nanoparticles, are characterized as particulate scatterings with a size in the scope of 10-100nm (Gubin et al, 2005). Attractive nanoparticles have increased a noteworthy enthusiasm for the most recent years both for fundamental research and applied examinations. The utilization of attractive nanostructures has been demonstrated in natural chemistry, biomedicine, and waste treatment among different fields. This wide scope of utilizations depends on the way that attractive particles have exceptionally enormous attractive minutes, which permit them to be shipped and driven by outside attractive fields. The attractive nanostructures have additionally an extraordinary potential in biotechnological forms considering that they can be used as a transporter for pro teins during various biocatalytic changes (Dussã ¡n et al, 2007). Various sorts of biomolecules, for example, proteins, compounds, antibodies, and anticancer operators can be immobilized on these nanoparticles. Attractive backings for immobilization reason for existing are either arranged by joining attractive particles during the combination of the supporting polymer or attractive particles itself be covered with basic help materials, for example, dextran or agarose. As of late, another strategy for the immediate official of proteins on attractive nanoparticles by means of carbodiimide initiation was proposed (Ren et al, 2011). Immobilization is one of the effective strategies to improve compound dependability. There are different techniques for immobilization of chemicals on various kinds of supports. It tends to be a compound strategy in which ionic or covalent security arrangements happen between the catalyst and the bearer, or it very well may be a physical technique, for example, adsorption or ensnarement of the protein in or on a strong help material. Attractive nanoparticles as immobilization materials have advantage dependent on its property and size that make it alluring for utilizing it in different applications (Mateo et al, 2007). Iron oxide nanoparticles, Fe3O4, are one of the broadly utilized kinds of attractive nanoparticles and have extraordinary potential for applications in science and medication because of their solid attractive properties and low poisonousness (Jalal et al, 2011) Survey of writing I) Magnetic nanoparticles: The recorded improvement of nanoparticles beginning with Paul Ehrlich and afterward first endeavors by Ursula Scheffel and partners and the broad work by the gathering of Professor Peter Speiser at the ETH Zã ¼rich in the late 1960s and mid 1970s (Jã ¶rg Kreuter 2007). They are strong particles with a size from 10 to 100nm which can be controlled utilizing attractive field. Such particles normally comprise of attractive components, for example, iron, nickel and cobalt. They have been utilized in catalysis, biomedicine, attractive reverberation imaging, attractive molecule imaging, information stockpiling , natural remediation and optical channels (Gubin et al, 2005). Attractive nanoparticles as immobilization materials have the accompanying points of interest: straightforward and modest creation, can be discharged in controlled way, stable attractive properties of complexed nanoparticles and simple confinement steps in brief timeframe. Among these materials, Fe3O4 attractive nanoparticles are the most normally contemplated. Fe3O4 attractive nanoparticles have great biocompatibility, solid superparamagnetism, low harmfulness, and a simple readiness process, and their utilization in biosensors has just indicated alluring possibilities (Sheng-Fu Wang and Yu-Mei Tan, 2007). II) Magnetic center material: There are numerous attractive materials accessible with a wide scope of attractive properties. for example, cobalt, chromium and iron oxide-based materials, for example, magnetite and maghemite. The reasonable attractive materials rely upon applications the MNP will apply in (Dobson et al, 2007). Magnetite Fe3O4: Magnetite is a typical mineral which shows ferro (ferri) attractive properties. The structure of magnetite has a place with the spinel gathering, which has an equation of AB2O4. Its ferromagnetic structures emerge from substituting cross sections of Fe(II) and Fe(III). This gives it an extremely solid polarization contrasted with normally happening antiferromagnetic mixes, for example, the ferrihydrite center of the ferritin protein (McBain et al, 2008). III) Synthesis of iron Magnetic nanoparticles: There were numerous combination techniques for attractive nanoparticles one of these is Co-precipitation. This strategy might be the most encouraging one as a result of its effortlessness and profitability (zhao et al., 2008). It is broadly utilized for biomedical applications due to simplicity of execution and requirement for less risky materials and strategies. Co-precipitation is explicitly the precipitation of an unbound â€Å"antigen alongside an antigen-counter acting agent complex† regarding medication (Indira and Lakshmi, 2010).The response guideline is essentially as: Fe2+ + 2Fe3+ + 8OH†⇠Fe (OH)2 + 2Fe(OH)3 â†' Fe3O4 + 4H2O (Guo et al., 2009). Other strategy utilized for combination like: Thermolysis of metal-containing mixes, union of attractive nanoparticles at a gas-fluid interface, union in turn around micelles and sol-gel technique (Gubin et al, 2005). IV) Characterization of MNP: There is no special technique for assurance of the nanoparticle arrangement and measurements; when in doubt, a lot of strategies including X-beam diffraction, Transmission electron magnifying instrument and Extended X-beam Absorption Fine Structure (EXAFS) Spectroscopy are utilized (Gubin et al, 2005). X-Ray diffraction examination of nanomaterial only here and there produces diffraction designs with a lot of thin reflections sufficient for recognizable proof of the creation of the particles they contain. Some X-beam diffraction designs display just a few widened pinnacles of the entire arrangement of reflections ordinary of the given stage (Moroz 2011). On account of bigger particles (gave that top notch X-beam diffraction examples can be acquired), it is frequently conceivable not exclusively to decide the stage organization yet additionally to evaluate, in light of the reflection width, the size of intelligible X-beam dissipating territories, relating to the normal crystallite (nanoparticle) size. This is typically done by the Scherer equation (Gubin et al, 2005). The nanoparticle measurements are resolved frequently utilizing Transmission electron magnifying lens, which legitimately shows the nearness of nanoparticles in the material under assessment and their plan comparative with each other. The stage creation of nanoparticles can be gotten from electron diffraction designs recorded for a similar example during the examination. Note that sometimes, TEM examinations of dynamic procedures are likewise conceivable. For instance, the improvement of separations and disclinations in the nanocrystalline during the mechanochemical treatment has been watched (Woehrle et al, 2000). Increasingly extensive data is given by high goals transmission electron microscopy, which permits one to examine the structure of both the center and the shell of a nanoparticle with nuclear goals, and now and again, even to decide their stoichiometric creation (Woehrle et al, 2000). The structures of non-crystalline examples are regularly concentrated by EXAFS spectroscopy. A significant bit of leeway of these techniques is its selectivity, since it gives the spiral circulation (RDA) bend for the iotas of the neighborhood condition of the picked synthetic component in the example. The interatomic separations (R) and coordination numbers (N) got by EXAFS are then contrasted and the known qualities for the specific stage (Gubin et al, 2005). Different techniques are utilized all the more infrequently to contemplate the nanoparticle structures. Coordinated research makes it conceivable to decide rather dependably the structures of basic nanoparticles; be that as it may, assurance of the structures of nanoparticles made out of a center and a shell of various arrangements are frequently confronted with challenges (Gubin et al, 2005). V) Stabilization of Magnetic Nanoparticles: In spite of the fact that there have been numerous huge improvements in the combination of attractive nanoparticles, keeping up the steadiness of these particles for quite a while without agglomeration or precipitation is a significant issue. Solidness is a vital necessity for practically any utilization of attractive nanoparticles. Particularly unadulterated metals, for example, Fe, Co, and Ni and their metal composites, are touchy to air. Consequently, the primary trouble for the utilization of unadulterated metals or combinations emerges from their unsteadiness towards oxidation in air, and the weakness towards oxidation becomes higher the littler the particles are (Lu et al, 2007). In this manner, it is important to create proficient procedures to improve the substance security of attractive nanoparticles: Surface Passivation by Mild Oxidation: A basic way to deal with ensure the attractive particles is to initiate a controlled oxidation of an unadulterated metal center, a procedure since a long time ago known for the passivation of air-touchy upheld impetuses. This oxidation can be accomplished by different techniques (Peng et al, 1999). For instance, Peng et al. built up a strategy for oxidizing gas-stage nanoparticles by utilizing a plasma-gas-buildup type group testimony mechanical assembly. Shown that very

Business Plan Essay Example | Topics and Well Written Essays - 1000 words - 3

Strategy - Essay Example Other speculation prerequisites will be financed by a $200,000 credit from Jabal Bank at a 5% loan fee repayable in two years. 3. Human asset plan Renowned hotelier Charles Duncan accused of the obligation of general business running and acquirement will oversee Emirates Restaurant. The executives premonition in previous administration endeavors in the business has won him numerous honors. He has experts in business organization from the Dubai University and has various effective spells in well performing inns and eateries in Emirates. The appointee the board will be Mark Weber who has a lone wolf in business Administration and is a perceived individual in the friendliness business. The delegate supervisor will be answerable for open connection, network improvement, and deals. Advertising obligations and deals, evaluating are additionally a portion of the duties to be attempted by the delegate director. Different workers to attempt the help jobs for the day by day running of the orga nization will incorporate five culinary experts prepared in cooking a bookkeeper to help in recording exchanges to the PC and the day by day acquisition and insignificant money installments. A security official to watch the premises and four servers to help in taking requests and conveyances will likewise be utilized by the organization. The quantity of workers will be expanded as need emerges when the administration want to enlarge the organization activities to fulfill expanding need. 4. Creation plan The creation plan at Emirates Restaurant is a principle aspect for the company’s improvement and achievement. This is confirm by the requirement for proficiency in stock administration and keeping up solid nourishments and high caliber for security of the shoppers. This will help in keeping away from exorbitant claims and a corrupt in the notoriety of the organization. I. Sanitation Apart from guaranteeing proficient creation, cautious stock dealing with by the workers of Emir ates Restaurant will help as a measure to limit food borne sicknesses. This guarantees no harm to customers, which can demolish the restaurant’s notoriety and rise of expensive claims. Emirates Restaurant will guarantee sanitation is kept up through fastidious stock turn and keeping food in pertinent temperatures. ii. Stock Management This involves the need by the administration and creation work force to guarantee the stock arranged are sufficient to meet requests made however in right amounts for use before they ruin. The fundamental explanation behind guaranteeing this is to stay away from overabundance stock. Abundance stock is bulky and hinder the creation procedure. Correlation of timespans corresponding to occasional interest vacillations are the techniques the administration will utilize in guaranteeing there is effectiveness in stock administration. iii. Worker preparing on dealing with Supplies Cases of unexpected conditions in the creation procedure remembering del ay for stock and breaking down of hardware require prepared and educated staff to guarantee practice regarding attentiveness as the circumstance requires. This will make effectiveness in the creation procedure and maintain a strategic distance from misfortunes to the eatery because of auspicious and cognizant modification of the creation procedure by the workers as the circumstance calls. iv. Keeping of Records Maintenance of present and point by point records of the creation

Artificial Intelligence In Military Technology Research Paper - 275 Words

Artificial Intelligence In Military Technology Research Paper (Research Paper Sample) Content: ARTIFICIAL INTELLIGENCE IN MILITARYName of the student:Name of the professor:Students class:Date:Artificial Intelligence in MilitaryIntroductionIn this paper, there shall have insightful discussion on the integration of the Artificial intelligence with an example of its use in the military docket. In the current warring activities, there has had a call for in-depth research on technology and invention of newer weaponry and intelligence with intents of curbing and countering all attacks. An example of the newest trend is the Turkish Defense industry which is currently almost ready to unleash an artificial Intelligence system of defense to better handle terrorism and evade the daily attacks with ease CITATION Bri101 \l 1033 (Marcathy, 2010). This is one of the many measures taken by the world countries in attempts of evading future attacks. The use of unmanned vehicles usually called the drones whether in the commercial or the military sector has been the bone of conte ntions with claims of its violations of human rights. Such weaponry which can either be in the air, under water may theoretically incorporate artificial Intelligence making them capable of executing attacks on their own. This debate has many stakeholders on the topic whereby some are for the benefits while others are on the negating effects brought about by the AI. Handed the complexity of this issue, there ought to have a definition of the term Artificial Intelligence. There does not exist any agreed definition even among the computer geeks on the definition of AI thus a general one inherently infers to a machine/device that selects and engages targets without much control of the human. In this paper, my position is agreeing a 100 percentile on the use of AI by the military with the sole purpose being the endangered human life from many angles inclusive of terrorism, and ambush attacks by enemies.Thinking of the robotsAn automated system is one whereby a computer makes its reasonin g by a clear if, then else rule structure with no determination insinuating that in each input, there shall have similar output or result CITATION Dee14 \l 1033 (Smitch, 2014). Conversely, an autonomous system infers to one with the resonating logic that relies on the probability of a given set of inputs meaning that it guesses on the best possible course of action on its own. This is only possible if it has sensor data input. Different from other automated systems, when same-handed behavior each time, instead, there shall have production of various ranges of behavior.There is a sequence followed by the human intelligence which is different from that of a robot. Human reasons for perceptions-cognition and later actions. Simply, this means that human perceives something within their environs, think about it, and later after weighing on the options, act CITATION Bri101 \l 1033 (Marcathy, 2010). Artificial intelligence is built by a human with the same concept with it processing afte r sensing the world near it, coming with a choice of action after thoroughly optimizing and verifying the needed algorithms.Benefits of Artificial IntelligenceArtificial intelligence is the new trend in the military all courtesy of the good deeds by the technology. One advantage of the AI is a defense to a country's citizens from attacks. If there had improvisation of detective devices, the 11th September bomb attack in the United States of America would not have occurred CITATION Dee14 \l 1033 (Smitch, 2014). The current use of drone can detect an attack from a far distance and through zooming, it is easy to have the weapon destroyed immediately or redirected and have retaliation moves. An example of the need for Artificial Intelligence is the North Korean launch of nuclear weaponry whereby none knows of the target and the timing. Here, Artificial Intelligence can be of much use by ensuring destruction of the weaponry in case it is launched. On the same issue, Artificial Intellige nce can help with the help of the world nations come up with plans to halt the intents of rival countries by secretly ousting leaders with world attacks and later aligning them in International Courts hence liable for their actions. Artificial Intelligence can aid in bringing about protection on the cyber security CITATION Bri101 \l 1033 (Marcathy, 2010). This is one issue on the rise with an example of the United States' mug of elections thus the best use of AI can assist in protecting databases of infrastructural facilities particular establishments of nuclear plants.Secondly, use of Artificial Intelligence in the military is a cost-cutting method in the military docket whereby there is few military personnel used who are replaced by the robots. Since the robots have higher intelligence in their build-up, it is easy to replace them with staff hence redirecting the expenditures used in payments and allowances to other developments of the nation. In a report from U.N, use of robots instead of armies in the peace keeping mission has been seen to have a reduction in expense by about $2,000,000 CITATION Bri101 \l 1033 (Marcathy, 2010).Thirdly, use of robots in any task makes work easy. In the military sector, there needs much personnel to handle various arsenals. This calls for deployment of vast number of staff. Fortunately, the invention of Artificial intelligence has positively impacted on the military docket whereby one robot has multiple weapons; guns, bombs and is a vehicle on its own thus ease of warring activity.The future of Artificial IntelligenceThe military engineers are the ones bearing the future of the AI since they have the capacities to designing autonomous systems ...

The Human Growth Associated With Each Lifecycle Group

Part-A Clearly describe the purpose of your assignment by identifying the groups and the development focus of each. The purpose of assignment is to understand the human growth associated with each lifecycle group. There are eight age groups with each has its own stage of development and related tasks. This assignment covers stage 4, â€Å"Identity vs Inferiority† middle childhood (6-12 years), †Identity versus Identity-Confusion† stage 5, (13-20 years) covering early childhood, and Intimacy vs. Isolation stage 6, (20-40 years), early adulthood. Identity growth and development is not identical for each group and each child and is depending on so many other things, how a child is raised by parents and supported by caregivers, exposed to the outside world and the environment. 1. Part-B Discuss how identity of self is developed in middle childhood and continued in adolescence and early adulthood including concrete examples of how growth occurs. Identity vs Inferiority stage of development is the stage of development during the age 6-12 years. During this stage the child develop the competence to know about himself and he is capable to compare himself to his parents, peers, caregivers, siblings, and other people to whom he is expose in community. He says thing like this, â€Å"This is my ball.† â€Å"I am faster than peter.† Child tries hard to win the approval of his social circle and if provided proper support by the parents, caregivers and peers he thinks proud of himself and becomes aShow MoreRelatedThe Heparin Sulfate As An Important Receptor For The It41703 Words   |  7 Pagescerebral malaria are caused in part by the expression of Histindine rich protein 2 (HRPII) (Pal et al., 2016). Cerebral malaria is caused by an inflammatory response and vascular leakage. HRPII is a diagnostic marker, due to the secretion it releases. Humans infected with the parasite, display high levels of the protein HRPII in their blood. 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The Renaissance And Italian Renaissance - 961 Words

The Renaissance (rebirth), was a time in which all art became more personalized and represented more than we see. There were two major stages in the Western European/ Italian Renaissance: Early Renaissance and High Renaissance. It gave patrons a new outlook on art and the world. Styles such as Mannerism, Fresco, and Parietal help advance art in western Europe. Most of the Renaissance works were religious,or had had something to do with the ancient times (ancient greece and roman culture). Not only was is a re-birth of art, it was a re-birth of scientific thinking and studying architecture. Although there are two major sections to the Renaissance, there are very few differences between the two periods of time in the 15th and 16th†¦show more content†¦Mannerism was huge in Italy. One of the greatest pieces created in this style was Leonardo’s ‘Mona Lisa’. Leonardo uses mysterious elements for the background, it recalls one of his other lesser known painting s named ‘Madonna of the Rocks’. The reason this piece is so fascinating is because Leonardo finished very few of his works. He did, however have a notebook of â€Å"Renaissance Drawings†. Since Leonardo was an architect as well as an artist, this led him to create some of the greatest technology man has ever known. They also resembled his ideas of what the Renaissance meant to him and the ideas he gained from this re-birth. Some of Leonardo’s tactics are still used today. Take cutaways for example. This style of imagery was used long before the age of X-Rays. Leonardo was not the only one with Renaissance Drawings. It was common for a lot of Renaissance artists to have notebooks full of drawings. Artists usually used silverpoint stylus when drawing in their notebook. For other works, artists used different materials (ink pen, chalk, charcoal, brush, graphite/lead). This has lead me to believe that artists used different materials to create different moods , and to give each piece a different meaning. Another big name in the Renaissance was Raphael (Raffaello Santi). It is said that Raphael mostly likely learned his tactics and roots of Renaissance art from his father, Giovanni Santi.Show MoreRelatedThe Italian Renaissance And The Renaissance1424 Words   |  6 PagesThe Italian Renaissance was an explosion of art, writing, and thought, that roughly lasted between 1300 to 1600. In this time each citizen, countrymen, or villager had and performed different jobs and careers. Humanism the study of Greek and Roman writings, art, and architecture, initially jump started the Renaissance, and the need for art. Artists now were inspired to use life like art and linear perspective, so art seemed and was more realistic. The start of the Italian Renaissance was theRead MoreRenaissance And The Italian Renaissance1396 Words   |  6 PagesThe Italian Renaissance had two distinct periods during its lifetime. The first being the â€Å"Early R enaissance†, which took place between the late 13th and the early 14th centuries. The second period was known as the â€Å"High Renaissance†, which took place during the 15th and 16th centuries. These two periods had very distinct foundations and styles behind the art and architecture of their respective periods. The Early Renaissance revived many old themes which later became the foundations for the HighRead MoreItalian Renaissance And The Renaissance910 Words   |  4 PagesIn the late 14th century to the 16th century, the Italian Renaissance was taking place and moving from the Middle Ages at a time when the Catholic Church was indomitable to a period called The Renaissance. 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Along withRead MoreThe Italian Renaissance1558 Words   |  7 Pages Julianna Plunkett Ms. McGuire British Literature 11 06/10/15 The Italian Renaissance began in the mid-fourteenth century, and was marked by a turn from medieval life and values dominated by the Church toward the philosophical principles of humanism. The Italian people, especially the educated middle class, became interested in individual achievements and emphasized life in this world, as opposed to preparation for life in the next world, which was stressedRead MoreThe Italian Renaissance870 Words   |  4 Pagescentury, Italy was divided into many self-governing city sates. Florence, an independent republic and third largest city in Europe at the time, was the motherland of the Italian Renaissance. This was an enlightening time of â€Å"rebirth† that began directly after the Middle Ages (History.com Staff). Florence was the birthplace of the Renaissance due to its location, prosperity, and cultural amalgamation. 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This differs greatly in todays society, as now woman’s primary function is not only to produceRead Mor eThe Rise Of The Italian Renaissance1287 Words   |  6 PagesThe Italian Renaissance, in contrast to the conservative attitude of the Middle Ages, introduced a society dominated by a secular, humanistic spirit. One of the most historically significant events of the Renaissance was the Reformation. Some people argue that the Reformation was a rejection the secular spirit of the Italian Renaissance. Others assert that the Reformation was an embracement of these secular ideas. However as with many questions, this issue cannot be given a definite answer. The events

Strategic and Operational Plans Based on the SWOT Analysis free essay sample

General Electric (GE), is an American multinational conglomerate corporation incorporated in Schenectady, New York and headquartered in Fairfield, Connecticut, United States. The company operates through five segments: Energy, Technology Infrastructure, Capital Finance and Consumer Industrial. In 2011, GE ranked among the Fortune 500 as the 26th-largest firm in the U.S. by gross revenue as well as the 14th most profitable. However, the company is currently listed the 3rd-largest in the world among the Forbes Global 2000, further metrics being taken into account. Other rankings for 2011/2012 include No. 7 company for leaders (Fortune), No. 5 best global brand (Interbrand), No. 63 green company (Newsweek), No. 15 most admired company (Fortune), and No. 19 most innovative company (Fast Company).( http://en.wikipedia.org/wiki/General_Electric) Based on the GE SWOT analysis will create and Strategic and Operational goals. Strengths Weaknesses Diversified product portfolio and revenue stream provides cross selling opportunities High indebtedness exposes to credit risk Successful inorganic growth strategy Dependence on third parties for raw materials Robust research and development capabilities Opportunities Threats Increased focus on energy sector http://www.ge.com/globalimpact/ecomagination.html?utm_source=gecomutm_medium=hp_seeutm_campaign=gecom_hp#!report=alternative fuelvehicles Challenging macroeconomic and political environment in the US and Europe New contracts to enhance top line growth Environmental and other government regulations Expansion of mining business Aggressive competition Strategic goals: Increased focus on energy sector In 2005 GE launched its Ecomagination initiative in an attempt to position itself as a green company. GE is one of the biggest players in the wind power industry and plans to build the largest solar-panel-making factory in the U.S., and has set goals for its subsidiaries to lower their greenhouse gas emissions. (General Electric, May 9, 2005) Recently, GE Capital’s Transportation Finance business and Clean Energy Fuels Corp., the largest provider of natural gas fuel for transportation in North America, have entered into a strategic alliance to accelerate the conversion of heavy-duty trucking fleets from diesel to cleaner-burning, less-expensive natural gas. To take advantage of this opportunity, truck fleet operators will first work with Clean Energy to develop natural gas fueling contracts, and will then apply for loans and leases, including fair market value leases, from GE Capital to acquire trucks from manufacturers that produce commercial natural gas vehicles (NGVs). Clean Energy will then help offset the monthly cost of newly-acquired NGVs to make it consistent with the cost of a diesel truck, if the customer makes a fuel commitment. (http://finance.yahoo.com/news/ge-capital-clean-energy-form-140100121.html) External and internal stakeholders will be influencing our strategic goal in difference way. Customers will appreciate lowing cost of fueling and the competition will be affecting as well. Increase Shareholders profit, which at the end is the primary goal of a corporate enterprise from the viewpoint of its shareholders is to maximize profits and enhance shareholder value. Operational plan: Reduces dependence on third parties for raw materials The company is reliant on third-party suppliers, contract manufacturers and service providers and commodity markets to secure its raw materials, parts, components and sub-systems used in its products. This reliance exposes GE to volatility in the prices and availability of these materials, parts, components, systems and services. A disruption in deliveries from the company’s third-party suppliers, contract manufacturers or service providers, capacity constraints, production disruptions, price increases, or decreased availability of raw materials or commodities, could have an adverse impact on GE’s ability to meet its commitments to customers or increase its operating costs. http://www.wikinvest.com/stock/General_Motors_(GM)/Raw_Materials_Services_Supplies Due to the extent of external factors and stakeholders, GE best way to confront this challenge is utilizing their own experience and for the most part predicts the exchange of suppliers. This could be achieving by the acquisition and trade of raw materials, suppliers and commodities. An example of this, GE Supply and Advanced trade of Materials was sold to SABIC, a Saudi government owned company, to offset the losses resulting from the price inflation of raw materials, natural gas, and benzene. (http://www.wikinvest.com/stock/General_Electric_Company_(GE)) References http://en.wikipedia.org/wiki/General_Electric General Electric, May 9, 2005. http://finance.yahoo.com/news/ge-capital-clean-energy-form-140100121.html http://www.wikinvest.com/stock/General_Motors_(GM)/Raw_Materials_Services_Supplies http://www.wikinvest.com/stock/General_Electric_Company_(GE)

One Flew Over The Cuckoos NestA Humanities Perspective Essays

One Flew Over The Cuckoo's NestA Humanities Perspective Ken Kesey's novel One Flew Over The Cuckoo's Nest takes place in a mental hospital. The main character, or protagonist is Randle P. McMurphy, a convicted criminal and gambler who feigns insanity to get out of a prisoners work ranch. The antagonist is Nurse Ratched also referred to as The Big Nurse . She is in charge of running the mental ward. The novel is narrated by a patient of the hospital, an American Indian named Chief Bromden. Chief Bromden has been a patient at the hospital longer than any of the others, and is a paranoid-schizophrenic, who is posing as a deaf mute. The Chief often drifts in and out between reality and his psychosis ( Kesey does a good job of blurring the line between the two). The conflict in the novel is between McMurphy and The Big Nurse which turns into a battle of mythic proportion. The center of One Flew Over The Cuckoo's Nest is this battle between the two, which Kesey uses to represent many of our cultures most influential stories. The dominant theme in this novel is that of conformity and it's pressure on today's society. In the novel conformity is represented as a machine , or in Chief Bromden's mind a combine . To the Chief, the combine' depicts the conformist society of America, this is evident in one particular paragraph: This excerpt not only explains the Chiefs outlook on society as a machine but also his self outlook and how society treats a person who is unable to conform to society, or more poignantly one who is unable to cope with the inability to conform to society. The chief views the mental hospital as a big machine as well, which is run by The Big Nurse who controls everyone except McMurphy with wires and a control panel( which the Chief see quite clearly in his psychosis). In the Chiefs eyes McMurphy was missed by the combine, as the Chief and the other patients are casualties of it. Therefore McMurphy is an unconformist and is unencumbered by the wires of The Big Nurse and so he is a threat to the combine. McMurphy represents the antithesis to the mechanical regularity, therefore he represents nature and it's unregularity. Another key theme in Kesey's novel is the role of women is society and how it contradicts the males. In keeping with the highly contrasting forces of conformity verses creativity Kesey proceeds to compare the male role to spontaneity, sexuality, and nature and the female role to conformity, sexual repression and ultimately the psychological castration of the male. Nurse Ratched was endowed with large breast which threatens her power over the male patients because of her exposing herself sexually and Kesey's view in the novel of male sexual dominance, therefore she try's to hide them the best she can. Nurse Ratched gains her power through her sterility which she does with no makeup and white uniform, as well as her emasculation of the male patients and doctors. The Big Nurse ' takes the place of the mother role or other over domineering feminine role in a lot of the patients lives, which led them to their psychological castration. To the Chief, the nurse takes on the role of his white mother who orchestrated the downfall and emasculation of his father and the selling of his tribal land to the white people ( also referred to as the combine ) . Another patient Billy Bibbit a thirty one year old man whose mental problems were due to his over domineering mother , who was friends with Nurse Ratched. The downfall of Billy was toward the climax of the novel when The Big Nurse brought to the surface Billy's inability to stand up to his mother and her years of psychological castration, and soon after, came his suicide. Kesey incorporates many other sub-themes into One Flew Over The Cuckoo's nest but all of them represent a larger than simply the battle between The Big Nurse and McMurphy. They all center around one central theme and that is the struggle between good and evil. This struggle shows up In many of Americas most definitive stories. And among these